Paul took this verse quoting Isaiah Chapter 64 where Isiah praised God for being Glorious to Israel, but at the end, he repented in intercession on behalf of Israel who have used the blessings of God to sin against God himself. Unfaithfulness and ungratefulness were their answer to God's blessings.

Be faithful and grateful to keep the Holy Spirit in you happy. Isiah ended the chapter 64 with a question that God answered to Paul in 1 Cor 2. God says that he gave us his Spirit, so we don't walk by might nor by power, buy the Spirit of God. The Holy Spirit was given to us. He lives within us. Jesus gave Him to us through our baptism. Holy Spirit reveals us God's wisdom.

Paul did not preach without Him. I can't preach without Him. Men can talk with the wisdom of science. But science and its wisdom are obsolete every 6 months now. The word of God remains for ever. The world moves by it. God is doing and will keep doing great things with us, those who use his Spirit to teach others.